| What are the short and long term effects of acute morphine poisoning with administration of naloxone?

What are the short and long term effects of acute morphine poisoning with administration of naloxone?

tracy asked:


I have been to several sites with this question, trying to learn as much as I can and understand what is going on.

One day post-op for neck surgery on C3,4,7 & T1 with titanium cage enclosure plus removal of multiple bone spurs on spine (front and back incisions), my husband was rushed to SICU due to acute morphine poisoning because of PCA by Proxy (his mother).

His resuscitation required three different attempts with three different medications, the first one being Naloxone. My husband was in SICU for 5 days and endured horrible withdrawals.

Why did he have withdrawals? What are possible complications of acute morphine poisoning? He has been discharged from the hospital, his neurosurgeon is reluctant to prescribe anything to effectively manage his pain. He is also experiencing night terrors when he dozes, but has insomnia.

Any information about acute morphine poisoning, and the antidotes, and the after effects of both will be greatly appreciated.

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Comments

One Response to “What are the short and long term effects of acute morphine poisoning with administration of naloxone?”

  1. Berry on April 24th, 2009 1:44 am

    WOW - PCA overdose by proxy. Never thought I’d hear of that! PCA stands for “Patient Controlled Analgesia”, not “Patient’s MOM”.

    The problem with any opiate overdose is that it suppresses the breathing drive in the brain control center. As long as his oxygen levels didn’t go down AND STAY DOWN for a prolonged period, there really isn’t any long term damage to morphine overdose.

    Naloxone reverses the effects of morphine, so a side-effect of Naloxone is acute morphine withdrawl. You can’t really adjust the Naloxone dose to just reverse a little of the morphine.

    Probably now he’s just having problems with pain control since the docs are worried about another overdose, this time with oral medications.